As chemists with experience in synthesis of important compounds against malaria, cancer and botulinum neurotoxin A, we believe that amongst our compounds ‘sitting on shelves’ and newly synthesized ones,that were not designed as antibiotics primarily, there is an interesting diversity to be screened for antimicrobial activity. The threat of antibiotic-resistant bacteria and fungi continues to rise, but the number of new treatments available has flatlined. Therefore, we carry out initial screen to test the potency of pure compounds against key ESKAPE bacterial pathogens Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, as well as fungal pathogens Candida albicans, C. parapsilosis and C. krusei.

• Bis-guanylhydrazones as efficient anti-Candida compounds through DNA interaction
  Jelena Lazić, Vladimir Ajdačić, Sandra Vojnovic, Mario Zlatović, Marina Pekmezovic, Selene Mogavero, Igor Opsenica, Jasmina Nikodinovic-Runic
  Appl. Microbiol. Biotechnol., 2018, 102, 1889-1901
• Synthesis and anti-Candida activity of novel benzothiepino[3,2-c]pyridine derivatives
  Nina Božinović, Sandra Šegan, Sandra Vojnovic, Aleksandar Pavic, Bogdan A. Šolaja, Jasmina Nikodinovic-Runic, Igor M. Opsenica
  Chem. Biol. Drug Des., 2016, 88, 795-806
• Synthesis, structural characterization and antimicrobial activity of silver(I) complexes with 1-benzyl-1H-tetrazoles
  Tina P. Andrejević, Andrea M. Nikolić, Biljana Ð. Glišić, Hubert Wadepohl, Sandra Vojnovic, Mario Zlatović, Miloš Petković, Jasmina Nikodinovic-Runic, Igor M. Opsenica, Miloš I. Djuran
  Polyhedron, 2018, 154, 325-333